Thyroxine during pregnancy - can I take?
Thyroxine can be taken during pregnancy.Moreover, if the thyroxine has been appointed for the purpose of replacement therapy, the dosage of it during pregnancy should be increased, since in this period in the body to produce more gamma globulin proteins that bind free thyroxine levels and to deprive him of the activity.
In some cases appointed thyroxine during pregnancy?
Thyroxine - is iodine-containing thyroid hormone Thyroid hormones: mechanism of action and physiological effects , formed from iodine that enters the body with food, and the amino acid tyrosine.Thyroxine (T4) is not biologically active hormone, but in human tissue by enzymes it is converted into an active hormone, triiodothyronine (T3).The blood is detected in the form of a thyroxine free and bound forms with Bellamy blood.Active influence on the body provides free thyroxine.Thyroxine regulates the secretion of pituitary thyroid stimulating hormone (TSH).
most common cause of thyroxine suppressive therapy during pregnancy is hypothyroidism - reduced thyroid function.
This is a very dangerous disease during pregnancy, since the lack of thyroid hormone can cause abnormal development of the child.Most often, a lack of iodine-containing thyroid hormones adversely affects the development of the central nervous system and thyroid gland.Especially dangerous is the condition in the first trimester of pregnancy when there is a bookmark of organs and tissues of the fetus.
Sometimes the presence of hypothyroidism in women can be detected only by laboratory diagnosis - studied the blood for thyroid hormones thyroid gland - is responsible for yourhormones .No other symptoms of the disease is not detected, and it is very dangerous, because if you do not assign a hormone replacement therapy suffer fruit.
That is why in preparation for pregnancy or after a pregnant woman becomes registered in the antenatal clinic, she is required to study blood for thyroid hormones.If their level is lower than normal, but this wee no symptoms of hypothyroidism (subclinical hypothyroidism, which is accompanied by an increase in pituitary thyritropic Gomonov at a normal level in the blood of free T4 and T3) still appointed replacement therapy.Replacement therapy require hypothyroidism and manifesting characteristic symptoms - and the level of TSH increases and free T4 and T3 reduced.
Hypothyroidism during pregnancy - is it dangerous?
Obstetricians today are able to cope with almost all the states that can occur during pregnancy.But just in case, if a pregnant woman becomes timely registered in the antenatal clinic regularly visits her and performs all the prescribing physician for diagnosis and treatment of diseases.Otherwise, it is impossible to guarantee anything, including child birth with severe developmental abnormalities.
subclinical hypothyroidism during pregnancy is dangerous for both mother and child.The ideal, of course, is to identify hypothyroidism prior to pregnancy, during its planning.In this case, the appointed replacement therapy with L-thyroxine Thyroxine - the main thyroid hormone individually selected dose.But the prescribed therapy in the first trimester of pregnancy also will be effective.
How is hypothyroidism during pregnancy
to treat hypothyroidism Hypothyroidism - Treatment: replacement therapy during pregnancy today prescribe a synthetic analogue of the natural thyroxine - levothyroxine or L-thyroxine.If hypothyroidism was diagnosed before pregnancy, the woman explained that to completely eliminate the negative effects, it is necessary to compensate for prior to conception.To that end, appoint a L-thyroxine in individually selected dosage that reduces the level of TSH in the blood up to 2.5 mkIE / ml (for women not planning pregnancy, above this level - 3 mkIE / ml).
After conception replacement therapy should be continued, while increasing the dose of L-thyroxine.
This is because during normal pregnancy amount of bound thyroxine is increased, whereas the level of free T4 and T3 is reduced due to the fact that increases blood levels of binding proteins, thyroxine.
How to be increased the dose, the attending physician decides.But usually the dose is increased by a third or half.If the TSH is below 2.5 mkIE / ml, the dose of the drug reduced appointed - a higher dose, appointed earlier, it has no negative impact on women and children.So as soon as a woman learns of her pregnancy, she should be prescribed by your doctor to increase the dose of L-thyroxine in the third.
In hypothyroidism plan observation and treatment of a pregnant woman enters blood test for hormones (TSH and free thyroxine) every two months.On the day of donation of blood for analysis do not take thyroxine.
accepted L-thyroxine once a day, in the morning half an hour before a meal.If a woman appointed as vitamin and mineral supplements for pregnant women, which include calcium carbonate, they must be taken at a different time, with a gap in time at least four hours, as calcium carbonate blocks the absorption into the blood L-thyroxine.
Chief during pregnancy is the fulfillment of all doctor's appointments antenatal clinic.