Steatosis pregnant - what danger?
- Fat steatosis pregnant - what is the danger?
steatosis pregnant commonly called acute fatty liver - a disorder that develops in some women during childbearing.This is a rare and potentially fatal disease, which usually manifests itself in the third trimester of pregnancy or shortly after birth.Steatosis pregnancy occurs in a 10000-15000 pregnant women.
Thanks to modern methods of diagnosis and treatment, mortality from this disorder in recent years has decreased significantly.In 1980, according to experts, it died about 75% of women who have been diagnosed with steatosis of pregnant women and up to 85% of their children.Today, the death rate among women with this diagnosis is 18%, among them children - about 23%.Surviving women sometimes develop liver failure because of what they ultimately may require liver transplantation.
Acute steatosis pregnant usually detected between 28 and 40 weeks of pregnancy, most often - at 35 and 36 weeks.There are some cases where the disease is manifested in the 26 week and soon after birth, as well as one case in which acute fatty liver was diagnosed at 22 weeks.
Just set a few early starts to develop this disease is very difficult because the other symptoms that appear in the majority of women in the third trimester,significantly complicate diagnosis.
Many patients that the violation causes non-specific symptoms such as anorexia Anorexia - Symptoms and effects on the body , nausea, vomiting, lethargy and general malaise, fatigue, headache Headache Causesand complications and abdominal pain.All these symptoms may occasionally occur during a normal pregnancy, so many patients ignore them for a long time, waiting for the improvement comes by itself.In 70% of patients eventually develop jaundice, but it is rarely one of the early symptoms of the disease.
In the survey, the patient may show increased sensitivity or soreness upper right side of the epigastric region (the area between the diaphragm and tenth ribs).The liver is usually small and palpable.In the most severe cases, both acute FH hepatosis Fat - Obesity liver cells can be observed violations such as acute renal failure Acute renal failure - causes and consequences , encephalopathy, gastrointestinal bleeding, pancreatitisand coagulopathy (blood clotting).Some women with acute FH also developing pre-eclampsia.
Causes and risk factors
During pregnancy, the mother's blood increases the level of free fatty acids - it is the result of hormonal changes.As a result, transport these acids into cells and their oxidation produces the energy required for the growth of the fetus.Defects in the genes responsible for these processes, can be transmitted from parents to children;they are known as fatty acid oxidation disorders.These defects are associated with a number of complications of pregnancy, affecting the health of the mother and fetus, as well as the functioning of the placenta.
During the last trimester of pregnancy the fetus in need of energy and nutrients is increasing, and women with a defective gene, the child also transferred this gene can develop acute fatty liver of pregnant women because the mother will not be able to process the free fatty acids in sufficient quantities.As a result, the fatty acids begin to deposit in the liver.Average fat content in the liver is about 5%, and for women with acute hepatosis pregnancy, this figure ranges from 13% to 19%.After birth, the level of free fatty acids is reduced, and in most cases, the patient recovers quickly.
presence of defective genes only means that a woman has a predisposition to steatosis pregnant;in fact, it may never have become ill.
factors, presumably associated with an increased risk of fatty liver in pregnancy: the first birth (especially aged 30 years and older), pre-eclampsia, pregnancy boy and multiple pregnancy.In addition, recent studies have provided evidence that acetylsalicylic acid and possibly other non-steroidal anti-inflammatory drugs may increase the chance of developing fatty liver of pregnancy.