Orungal - antifungal broad spectrum


orungal Orungal - a modern, effective antifungal agent active against most pathogens of fungal infections.It produces orungal pharmaceutical company Janssen Pharmaceutica (Belgium) in the form of capsules and oral solution.

Orungal - especially action

Orungal - a modern antifungal drug broad spectrum of action.Active substances it is itrikonazol.It is produced only in dosage forms for oral administration (capsules and solution).Upon receiving orungala it is rapidly absorbed in the intestine and enters the blood is distributed in the body, while its concentration in the skin and nails are several times higher than in blood.In the tissues of the internal organs it is also more concentrated than in the blood.The highest concentration in the tissues orungala achieved two weeks after his regular admission.It decomposes orungal hepatic metabolism of numerous products, some of which also possess antifungal effect.Excreted in the bile and urine.

When injected into tissue, infected with pathogenic fungi, orungal prevents the formation in the cell membranes of fungi of ergosterol, leading to the death of these cells.

sensitivity orungalu show most pathogenic fungi that cause disease in humans.The only exceptions are a few quite rare, including tropical fungi that cause diseases such as zygomycosis, fizarioz, skopulyariopsioz and alleshiroz.

Under what fungal infections will orungal

Orungal used for fungal infections caused by susceptible pathogens to it.This is a fungal disease of the skin (microsporia trichophytosis, jock itch Inguinal athlete: fungal infection Jock itch: fungal infection , athlete's foot, ringworm colorful Colorful lichen: relapses Colorful lichen: relapses , candida skin lesions and so on), mucous membranes (candidiasisor thrush), nails (onychomycosis caused by various pathogens of fungal infections), eye (fungal keratitis) and systemic fungal infection that affects the internal organs, including the brain.

Contraindications for use

orungala peculiarity is that it is not combined with the reception of many other medicines that are degraded by the liver via the same enzyme belonging to the family of cytochrome, - CYP3A4.The use of such medicines at the same time strengthen its orungalom side effect on the heart - the heart muscle is reduced with a smaller force.These drugs include terfenadine, astemizole, mizolastine, cisapride, dofetilide, quinidine, pimozide, Levo, sertindole, simvastatin and lovastatin, oral midazolam and triazolam.In addition, together with orungalom can not be applied preparations of ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine and metilergometrin.Orungal also contraindicated if you are hypersensitive its components the body of the patient, pregnancy and breast-feeding Breastfeeding - a personal choice Breastfeeding - a personal choice feeding.

wary orungal prescribed for disorders of the liver, kidneys and cardiovascular system.

What side effects may give orungal

Orungal provides few side effects.The worst side effect is the suppression force of heart contractions (mainly due to the reduction of potassium in the blood).This leads to the fact that the blood in the large and small circles of blood circulation stops and starts effectively pumped stagnate.Stagnation in the systemic circulation leads to edema, and small - to a violation of the respiratory function and the appearance of shortness of breath.In healthy people, these side effects usually do not happen, but those who suffer from disorders of the cardiovascular system, liver (liver orungal decomposes) or renal (kidney displayed through a significant part of it) side effects can be quite heart.Similar problems may arise while taking orungala simultaneously with several other drugs.

In addition, side effects may occur on the part of the digestive system in the form of nausea, vomiting, diarrhea, abdominal pain, constipation, transient liver dysfunction (in very rare cases develop chronic hepatitis).From the nervous system can cause headaches, dizziness, neuralgia Neuralgia - the scourge of the elderly Neuralgia - the scourge of the elderly .In women, the menstrual cycle is possible.There are also various types of allergic reactions from hives to the syndrome of Stevens - Johnson (severe lesions of the mucous membranes of the internal organs).

Orungal - is an effective antifungal agent.Like many other antifungals, it can produce side effects, and should be used only on prescription.

Galina Romanenko