and amitriptyline and alcohol have a significant impact on the central nervous system of mutually reinforcing their action.These substances have a similar impact on some of the internal organs, making the combination of amitriptyline with alcohol is very dangerous.
How does the body amitriptyline
Amitriptyline increases or suppresses the content in the brain of certain neurotransmitters - biologically active substances that transmit information from one nerve cell (neuron) to another.Such an action can not affect the state of the central nervous system (CNS) in general.The main effect of amitriptyline is to restore the patient's emotional state (depression, withdrawal Depression - a little more than a bad mood , anxiety and fear).It also has a pronounced calming effect.
But amitriptyline has many side effects, which can manifest itself in the oppression of the central nervous system in the form of movement disorders (sometimes persistent), and speech disturbances, headache, dizziness
numerous side effects it causes and other organs and systems: attacks heartbeats and cardiac arrhythmias, changeable blood pressure, various disorders of the gastrointestinal tract, liver problems, hormonal disorders, and so on.
How does the body alcohol
Alcohol acts on the body bi-phase.In the first phase it causes the excitation of the central nervous system, and all related effects, and the second - a persistent inhibition of the central nervous system.That is the effect of the second phase coincides with the action of intoxication of amitriptyline.Suppression activity of the central nervous system of alcohol and concerns of vital functions.
especially dangerous depression of the respiratory center - this is the effect of alcohol often causes the death of people in a state of extreme intoxication.
In addition, alcohol is hepatotoxic poison, meaning it can destroy the liver cells.
How does the body combination of amitriptyline and alcohol
amitriptyline enhances the inhibitory effect of alcohol on the central nervous system.When combined with alcohol amitriptyline patient can rise very high temperature, developed a paralytic ileus.And amitriptyline and alcohol increase the content of norepinephrine in the central nervous system - the substance that stimulates the cardiovascular system and raises your blood pressure - this can lead to serious cardiac arrhythmias and hypertensive crisis, which may end with stroke and myocardial infarction.
Imminent danger in the combined use of amitriptyline and alcohol arises from the oppression of these substances in the breathing center of the brain - the smallest overdose can lead to respiratory arrest stop breathing (apnea) during sleep - upper airway obstruction and deathpatient.
Finally, amitriptyline and alcohol are toxic to liver cells that at the time of their simultaneous use can lead to toxic necrosis of the liver - a condition difficult to compatible with life.
Concomitant use of amitriptyline and alcohol causes severe drowsiness or agitation, slowness and blurred speech, disorientation to time and place of residence, confusion and impaired consciousness (even coma), a sharp persistent mydriasis, significant fever, shortness of breath or cessation of breathing, hallucinations, seizures, rigidity (stiffness), muscle, heart rhythm disorder.
amitriptyline is rarely used in the treatment of chronic alcoholism, as in patients with this disease often have contraindications to receiving this drug from the cardiovascular system and liver.
How to help a sick
It must be remembered that the concomitant use of amitriptyline and alcohol is dangerous for life, so do not wait until the patient becomes very ill, you need to call an ambulance.While the ambulance was going, the patient must wash out the stomach.To do this until he is conscious he needs to drink one to two liters of water and push the root of the tongue to induce vomiting.If a lot of food in the stomach, it is possible to repeat the procedure.After gastric lavage should be given to the patient to take a few tablets of activated charcoal Activated carbon - old but indispensable , which adsorbs to the surface and removed from the body naturally balances amitriptyline and alcohol.Further medical treatment should be carried out in a hospital.
patients taking amitriptyline, have a very good understanding of what can happen if at the same time take the drug alcohol.