Today depressive and anxiety disorders occupy one of the top places among mental illnesses Mental illness - ashamed to ask for help? .At the beginning of this century, they accounted for about 40% of the total registered in the world of mental disorders.It is noted that the growing resistance (nevosprpriimchivost) depressed to some medicines.
What is depression
Depression - a mental disorder that is accompanied by a depressed, sad and depressed mood disorders, combined with thinking, movement and operation of the internal organs.Depression refers to a group of affective disorders, which are characterized by pathological changes of mood.Depression occurs in almost all mental illnesses, but they manifest themselves in different ways.
Depression tend to repeat, so the negative impact on quality of life.The basis of depression is a decrease of brain activity through the development of limiting inhibition with extreme exhaustion and subcortical inhibition of instincts.
How does depression
simple form of depression characterized by the following symptoms: depressed mood, motor and mental inhibition.Initially, the patient has fatigue, sadness, fatigue, and sometimes - anxiety Anxiety - how to distinguish normal from disease? or vicious scowl.Gradually, they are joined by a dissatisfaction and its actions.They are "lazy rolls," they "do not want to move hand or foot."Patients consider themselves "unfit to anything standing" of the feeling of joy and happiness, they want to be alone.Dream becomes restless, disturbed sleep process, patients eat poorly, they are concerned about constipation and persistent headaches.
With increasing severity of the disease the mood is deteriorating more and becomes a "black melancholy."The peculiarity of this angst is its physical sensation in the chest, the heart, the head of "heartache" or "hard rock."
In severe depression, patients are immobile, suppressed expression of grief or absent.Sad eyes, eyelids Semi-underslung, voice quiet, monotonous, talking quietly, in monosyllables, as if with difficulty.Gradually, the thought of his inadequacy and sinfulness can lead them to thoughts of suicide.These states may be interrupted by the explosion of a sudden feelings of despair, hopelessness with groans, the desire to inflict self-injury and suicidal.Patients lose weight, they observed a decrease in blood pressure, hormonal background (impotence in men and cessation of menstruation in women), and so on.
addition to typical depression there are other manifestations of it, "tearful", "smiling", anxiety depression and so on.
treat depression drugs, which are called - antidepressants.The choice of antidepressant depends on the form of depression Depression - a little more than a bad mood .There are three groups of antidepressants:
- predominantly psychoactive (stimulating) effect;
- with a broad spectrum of action, but with a predominance of thymoleptic effect (improve mood);
- predominantly sedative timolepticheskoe or sedation (calm and improve mood, or simply soothe).
Depending on the prevalence of depression in those or other signs of anti-depressants are selected with a certain effect.
problem of resistance in the treatment of depression
During treatment of depression in many patients revealed resistance (immunity) to a particular drug, and sometimes all antidepressants.This resistance is not uncommon, and sometimes a serious problem.Currently, resistance to antidepressants has been well studied and it is divided:
- primary or true resistance - of immunity, which is linked to the genetic characteristics of the patient (for example, with reduced sensitivity to nerve endings it), or with severe disease;
- the secondary resistance - the effect of habituation (adaptation of the body) to a particular drug in its long-term use;
- on psevdorezistentnost, which is linked to the inadequacy of the patient assigned to this treatment (the drug of choice inaccuracy, lack of the dose, the dose calculated without taking into account other conditions, such as those that violate the absorption of the drug);
- a negative resistance - increased sensitivity to the development of side effects when taking antidepressants, the severity of which is so high that the drug should be discontinued.
All types of resistance cooperate.For example, even if patients with primary resistance to achieve positive effect in the future, this effect may be reduced because of the connection resistance due to the negative effects of allergy to the drug.
In order to overcome the resistance of patients with depression, antidepressants, doctors consider many factors: the correct (according to the availability of certain signs of the disease) is chosen antidepressant is prescribed adequate doses of it, taking into account the presence of the patient or other comorbidities, pickthe most suitable for this patient the route of administration.For successful treatment it is necessary that the patient's blood is constantly maintained concentration of antidepressant exceeds a certain minimum level.Only in this case, the treatment of depression Treating depression - tablets needed be effective.