Manic-depressive illness - which are the most dangerous phase?
- Manic-depressive psychosis - what phase are the most dangerous?
- dangerous phase
Recently largely reviewed the causes of bipolar disorder, but the importance of heredity is not denied by anybody.Moreover, new studies confirm the fundamental role of heredity in the development of this disease.
Evidence for the role of heredity in the development of manic depression
final cause of manic-depressive psychosis (MDP) is not clear, but modern researchers are increasingly coming to the conclusion that the disease is polyetiological, that is calledvarious reasons.The role of heredity in this case there is no denying it is still considered the main cause of the disease.
a result of numerous studies in the past and in the present, found that in families of probands (people who make up for the Pedigree, brothers and sisters of the proband are called siblings) with suspected TIR incidence of this disease is much higher than in the general population.At the same time it increased the number of patients in the descending generations as compared to the rising: in the general population in the proportion of patients TIR account for about 0.4%, while the parents of the proband - from 7 to 23%, and the children of the proband - up to 33%.
twin method importance of heredity was revealed clearly: family history among siblings was diagnosed in 18% of patients, among dizygotic twins If you have twins:Ten Smiles - 23% among monozygotic - 92% - all this suggests that matters the degree of blood nearby.
In families where there are sick TIR and constitutional characteristics of personality: some of them are inherited, and formed part of the social environment.These are people with tsiklopodobnymi mood swings, their number increases depending on the degree of kinship with the patient TIR: 0.7% in the population, parents of patients - 14.5%, the brothers and sisters - 12.9% in dizygotic twins - 30% between identical - 37%.
In families where there are sick TIR identified as schizophrenia Schizophrenia - to blame civilization and other mental illnesses Mental illness - ashamed to ask for help? , the number of which increases with each generation.
Heredity in different types of manic-depressive psychosis
in recent years established a connection with the character of the current TIR role of heredity in the development of the disease.Within the TIR can be monophasic (unipolar) prevails when one phase of the disease (often it happens depression Depression - a little more than a bad mood and very rarely - mania) bipolar and when there are two phases, successive (depression and mania).
While numerous studies have found that patients with bipolar course TIR marked a pronounced family history than with monopolar current.In the first case, the disease starts earlier (at a younger age) and more severe.
These studies have raised the assumption that patients with unipolar MIS over the development of the disease largely caused by mental stress, exhaustion of regulatory systems in the brain and to a lesser degree - heredity or other organic changes in the brain.In patients with bipolar over the TIR has a rougher, hereditary or acquired brain damage, which leads to disruption of the regulatory powers of the brain.
confirmation of this study is that family history was detected in patients with bipolar disease course more often than monopolar.Furthermore, it was found that patients with bipolar course TIR which showed no hereditary "roots" of the disease, the cause of the disease has been the combination of external actions with organic changes in the brain (impact injury, disease and so forth).
have also been studied and constitutional features of patients with mono- and bipolar course Carnet.It was established that during the bipolar TIR often develops in people with normotimnym character without pronounced mental disorders.During monopolar TIR occurs mainly in people with psihostenicheskimi traits that are not self-confident, very conscientious and careful.
What happens in the brain of the patient
Today found that the development of MIS associated with impaired transmission of nerve impulses in the brain, particularly the hypothalamus and other brain areas responsible the formation of major mental reactions such asmood, feeling, waking, the rate of mental reactions, and so on.Transfer violated in synapse (the junction of individual neurons), due to a lack of neurotransmitters - biologically active substances, which are transmitted via pulses.
Manic-depressive psychosis - is a complex, not yet fully understood disease in which heredity plays a significant role.