Eskapel - extra protection against unwanted pregnancy

  • eskapel - extra protection against unwanted pregnancy
  • What eskapel

Eskapel eskapel is the so-called emergency contraceptive Emergency contraception - do no harm! Emergency contraception - do no harm! - he used when not worked, or for some reason can not be used contraception the first choice.The active ingredient is eskapel levonorgestrel, which prevents fertilization.If fertilization has occurred, it can cause changes in the endometrium that hinder implantation of the embryo, but the contraceptive effect in this case is reduced.

eskapel prevents pregnancy in 84% of cases.The sooner after intercourse the woman will eskapel, the greater the likelihood that the pregnancy will not occur.When used properly, the preparation has no significant effect on blood clotting factors and fat and carbohydrate metabolism.


eskapel Following oral administration is absorbed rapidly and almost completely.The content of drug in the blood reaches a maximum - 18,5 ng / mL - an average of two hours.Then, the levonorgestrel begins to decline pretty quickly.The half-life of the drug - 26 hours.Levonorgestrel metabolites are excreted in about equal proportions with urine and stool.In the liver, the hydroxylation occurs levonorgestrel, from where it is output in the form of the glucuronide.Pharmacologically active metabolites of levonorgestrel are not currently known.

Levonorgestrel is bound to serum albumin and SHBG (globulin, sex hormone binding).65% of the dose eskapel binds with SHBG, and only 1.5% is present in serum as free steroid.

After a single oral eskapel average value of SHBG in serum reached approximately 40 nmol / L.It remains at this level or even increased slightly within 24 hours, and then gradually decreases and within 192 hours reaches the level of 30 nmol / L.The absolute bioavailability of the drug is estimated almost one hundred percent.


Emergency contraception within 72 hours after unprotected intercourse, while others use contraception failed.


  • hypersensitivity to the drug
  • severe hepatic insufficiency
  • Pregnancy or suspected pregnancy

Reception eskapel lactation is allowed only after consulting your doctor.Since breast milk output of about 0.1% of the dose of levonorgestrel.To reduce the impact of the drug on the baby should be taken eskapel immediately after feeding and during the next 24-48 hours to feed the baby from a bottle.


eskapel a means of emergency contraception and should be used only in extreme cases.It is not intended for regular use.Eskapel not guaranteed to prevent pregnancy.

If unprotected intercourse occurred more than 72 hours before receiving eskapel pregnancy could occur, and the drug is not able to interrupt it.

If after receiving eskapel a delay menstruation, need to do a pregnancy test.If pregnancy occurs during the same cycle when a woman takes eskapel, there is an increased likelihood of ectopic pregnancy.This risk is particularly high for women, whose history has an ectopic pregnancy Ectopic pregnancy - Fatal dangerous Ectopic pregnancy - Fatal dangerous , surgery on the fallopian tubes and pelvic inflammatory disease.

Drug Interactions

following drugs can decrease the effectiveness of eskapel and other contraceptives containing levonorgestrel: barbiturates (including primidone), phenytoin, carbamazepine, herbal medicines containing St. John's wort, rifampicin, ritonavir, rifabutin, griseofulvin,ampicillin and other antibiotics Antibiotics - whether they will help you in the foreseeable future? Antibiotics - whether they will help you in the foreseeable future? , including medicines used to treat tuberculosis Treatment of tuberculosis - a lengthy process and requires constant monitoring Treatment of tuberculosis - a lengthy process and requires constant monitoring , cyclosporine.

Furthermore, levonorgestrel can inhibit the metabolism of cyclosporin, which is why the level of the drug in the blood can become dangerously high.

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