Exoderil during pregnancy - the application is not desirable
Exoderil - is an antifungal drug that is only available in dosage forms for external use - in the form of a solution, gel and cream.Exoderil during pregnancy can not be used due to the fact that some of the activities of the active substance can be absorbed into the bloodstream and to the general (systemic) effect on the body.
How does ekzoderil
Exoderil The composition includes active substance naftifine - antifungal agent of the allylamine.Another widely used today allylamine is terbinafine (limizil).
Exoderil highly lipophilic, that is, the tendency to accumulate in fatty tissue.When applied to the skin, it penetrates well into all of its layers, creating in them a concentration sufficient to suppress the vital activity of cells and destruction of the main pathogens of fungal infections fungal infection: to prevent and defeat .Exoderil penetrates through the skin layers and the average is stored in the lipophilic stratum corneum (outer) layer of the skin, and then excreted by the sebaceous and sweat glands, thereby creating high concentrations in the hair follicles, sweat glands area.The mechanism of action Exoderil Exoderil - treats fungal infections associated with suppression of the synthesis of ergosterol - a substance necessary for the construction of the cell membranes of fungi.This leads to the destruction of fungal cells.
ekzoderil accumulates in the nail plate.Therapeutic concentrations in nails is achieved during the first few weeks, and stored up to six months after treatment, but in the end (which is to be circumcised) of the nail therapeutic konetsentratsiya saved less long, for no more than two months after the cancellation.The rate of penetration into the tissue of the nail Exoderil exceeds its rate of growth.
However, about 6% of the active active substance can enter the bloodstream and have systemic effects, penetrating into many tissues.Ekzoderil displayed for two - three days with urine and feces partially intact, and partially as metabolites (metabolic products).
How does ekzoderil pregnant women
But nobody knows, since tests Exoderil in pregnant women were not conducted.However, laboratory studies were carried out on animals which have not confirmed the fact of the (including mutagenic or teratogenic) effects Exoderil on the body of the pregnant woman and the fetus.Thus, rats and rabbits were administered an oral dose of the active substance acting ekzoderil naftifine 150 times and more greater than the dose for humans when applied topically.
Nevertheless, naftifine may enter the bloodstream and exert the overall effect on the organism, so its use during pregnancy is not desired.Of course, when used correctly by a physician naftifine negative impact on a woman's body and the fetus is unlikely.Yet such a development can not be completely excluded.
Why ekzoderil is a danger to pregnant women
It is evident that for most women is no danger in the external application Exoderil not.At the same time for some of the negative effects of women this drug on the fetus is possible.
This is due to the fact that the blood is sucked into the 6% naftifine degraded in the liver and excreted by the kidneys after or intestine.Different women work of these bodies has its own characteristics.So, very often the physiological characteristics of the enzymatic activity of the liver.That liver enzymes contribute to the decomposition of a substance in the metabolic products (metabolites).Excretion of the same substance and its metabolites through the biliary tract and intestines or blood through the kidneys and urine.All these bodies may have their physiological characteristics, as a result of which certain substances can accumulate in the body.
for pregnant women, bodies that work with high load, and sometimes show tissue complete unpredictability of the effects of a substance, even such small concentrations in the blood can make a difference.That is why the pharmaceutical companies that manufacture a variety of drugs are always very cautious about the possibility of their appointment to pregnant women.
ekzoderil can apply to pregnant women or not?
This question should be decided by the attending physician.It depends on the type of fungal infection, the general condition of pregnant women and fetal condition.If the use of this drug really needed a pregnant woman, the doctor takes the responsibility of his appointment.Independently apply any Exoderil dosage forms (despite the fact that it is applied only topically) is absolutely contraindicated for pregnant women.