Pregnancy and Roaccutane - can not combine

Pregnancy roakkutan Roaccutane - a drug for the treatment of acne Acne treatment: how to get rid of blackheads Acne treatment: how to get rid of blackheads , which includes a retinoid, or a synthetic analog of vitamin A. Vitamin A needs during pregnancy, but in small amounts in the form of short courses.Overdose of vitamin A is very dangerous for pregnant women because it may cause fetal abnormalities.


structure and mechanism of action of Roaccutane

active substance is a retinoid isotretinoin Roaccutane.This drug is produced only in the form of capsules for oral administration and has a general (systemic) effect on the body.

Action Roaccutane related to the suppression of proliferation (proliferation) and differentiation (specialization tissue cells, they differ from other cells), epithelial cells lining the sebaceous glands.It accumulates in these cells, and then discharged outside sebum.Additionally, isotretinoin helps normalize the chemical composition of sebum and dead cells dissolution (keratolytic action) - these cells are mixed with sebum, sebaceous gland is sealed, there multiply pathogens suppurative inflammatory process that leads to the formation of acne.

Roaccutane does not have anti-bacterial and anti-inflammatory properties, but increased saloobrazovaniya suppression and changes in the composition of sebum along with keratolytic action helps to ensure that infectious agents multiply less active inflammatory process and is not developing.


What is dangerous for pregnant women Roaccutane

Roaccutane contains high doses of retinoids - synthetic analogues of vitamin A. Today, it is well establishedthat high doses of the vitamin have teratogenic effects, that is, cause various malformations in the fetus, which is obviously due to the suppression of cell proliferation and differentiation of tissues.It may be some anomalies such as cleft lip and cleft palate, do not allow your child to suck and swallow normally.There may be more significant anomalies, for example, from brain (microcephaly, hydrocephalus, etc.), with the circulatory system (high heart disease), and other organs and systems.In addition, it increases the risk of miscarriage Miscarriage - why you lose the most precious thing? Miscarriage - why you lose the most precious thing? .

Vitamin A is necessary for an organism of the pregnant woman, but not in such doses.The situation is exacerbated by the fact that pregnant women are reduced functional activity of the liver, whereas retinoids (as well as natural vitamin A) accumulates in the liver and adipose tissue and are used by the body slowly.This further contributes to a drug overdose.

Roaccutane has other side effects:

  • on the part of the brain and sensory organs - headaches, bouts of depression, increased intracranial pressure, seizures, various visual and hearing impairment;
  • the part of the digestive system - nausea, inflammation of the walls of the small intestine and colon, gastrointestinal bleeding, pancreatitis, transient liver problems, sometimes - hepatitis Hepatitis - the scourge of our time Hepatitis - the scourge of our time infectious origin;
  • from the musculoskeletal system - joint pain Joint pain - how to understand what is going on? Joint pain - how to understand what is going on? and muscles, hyperostosis (pathological proliferation unmodified bone, including compression of the spinal column with the spinal cord) and other bone changes;
  • in the blood - a decrease in white blood cell count (leads to a decrease in immunity and development of infectious and inflammatory processes), red blood cells (anemia), and platelets (increased bleeding) in the blood;
  • moreover, lymph nodes may increase, the appearance of protein in the urine and blood development vasculitis (inflammation in the walls of small blood vessels).

When receiving Roaccutane may also increase cholesterol and uric acid in the blood, which increases the risk of developing cardiovascular disease.


Pregnancy and Roaccutane: manufacturers warn

manufacturer of Roaccutane is a Swiss pharmaceutical company F. Hoffmann-La Roche Ltd.The company has developed a number of requirements for the use of Roaccutane in women of childbearing (reproductive) age, in order to avoid the risk of teratogenic effects of the drug on the fetus.Roaccutane can not be applied to women of reproductive age.The exceptions are women:

  • with severe acne that had previously unsuccessfully treated by other methods of treatment;
  • women who know about the teratogenicity of Roaccutane and that it can not be taken, both during pregnancy and during the months prior to its occurrence;if they agree to comply with all the requirements of a doctor, including the use reliable contraception;while a woman must certify in writing that he understands why those precautions required;
  • surveyed pregnancy two weeks before the start of treatment;further pregnancy tests should be performed on a monthly basis, as well as after treatment;
  • during one menstrual cycle before treatment, during treatment (course begins third day of the next menstrual cycle) and one menstrual period after the end of a woman (even if she is suffering from infertility) should use reliable methods of contraception.

thus experimentally confirmed teratogenic effects of Roaccutane, not allows the use of this drug during pregnancy and during its planning.

Galina Romanenko