Ursosan for newborns - is better to replace the analogue
Newborns often develop jaundice, called physiologic and does not require treatment.But sometimes the physiological jaundice is prolonged in this case, the newborn treatment is prescribed.There are other types of jaundice in the newborn to be treated.
Physiological neonatal jaundice
Physiologic jaundice due to an increase in blood bilirubin Bilirubin - a great tool for the diagnosis , thus there is staining of the skin and mucous membranes yellow.Bilirubin - a substance that is formed by the breakdown of hemoglobin Hemoglobin: worse - low or high? , contained in red blood cells.Immediately after the birth of hemoglobin, which acts as a carrier of oxygen in utero (fetal hemoglobin), is destroyed and replaced by adult hemoglobin is formed.With the destruction of large amounts of fetal hemoglobin is released much bilirubin, which is called the indirect or unrelated, it is insoluble in water and therefore is not excreted in the urine.Later indirect bilirubin goes to the liver, where it binds to glucuronic acid and loses its toxicity - this is called direct bilirubin, or linked, it is easily excreted from the body in urine.
But the problem is that in the liver of a newborn still do not have enough enzymes for converting indirect bilirubin into direct, and therefore develop jaundice.This jaundice can begin 2-3 days after birth and continue for two weeks.Longer for jaundice dangerous as possible toxic effects of indirect bilirubin in the brain cells with the defeat of his subcortical nuclei.Long flowing jaundice to brain damage called nuclear, it can have dire consequences for the child.Therefore
for neonatal jaundice carefully monitored several times bled for analysis in the case of prolonged jaundice prescribe the necessary treatment.Treatment of the physiological neonatal jaundice should be complex.The structure of such treatment neonatology today typically comprise a medicament active ingredient which is ursodeoxycholic acid.
The drugs on the basis of ursodeoxycholic acid on infants with physiological jaundice
For drugs, active substances which is ursodeoxycholic acid, areursosan and ursofalk.Ursosan issued Czech pharmaceutical firm PRO.MED.TSS capsules of 250 mg and ursofalk - German pharmaceutical firm DOCTOR Falk Pharma capsules of 250 mg in the form of a suspension for oral administration in bottles of 250 ml with measuring spoon of 5 ml (5 ml containing 5 mg of active substance).For newborns, certainly, the dosage form of the drug in suspension is preferable - it is easier to dose and give the child.
Ursodeoxycholic acid is hepatoprotector (a substance which has a beneficial effect on the liver function) with a pronounced choleretic effect.Under the influence of drugs containing ursodeoxycholic acid, the cells of the liver of a newborn baby will mature and begin to produce the right amount of enzymes to convert indirect bilirubin in a straight line, ie a reduction in the toxic effects of bilirubin in the body.Of particular importance it has for the brain - it prevents the possible development of kernicterus.
At the same time under the influence of Ursosan (or Ursofalk), improves the outflow of bile biliary pathways and removing stagnation of bile, which further improves the function of the liver.
prescribe drugs based on ursodeoxycholic acid newborn (like any other medication) can only be a doctor, it also determines the dosage and duration of administration of the drug, which serve as the basis for laboratory data (blood bilirubin) and the child's condition.The daily dose is usually given once a child.
contraindications for prescribing based on ursodeoxycholic acid and their side effects
Preparations based on ursodeoxycholic acid is not prescribed to babies if they have disorders of the liver and kidneys, as well as the child's hypersensitivity to the drug.
These drugs are usually very well tolerated by infants, but in some cases, possible side effects:
- from the gastrointestinal tract - a child may appear persistent vomiting or even vomiting, he becomes restless;
- of the liver - can appear transient disturbances of its function;
- possible allergic reactions Allergic reactions: how to understand why you tickle in the throat .
Preparations based on ursodeoxycholic acid is now widely used for the treatment of jaundice Jaundice - if the eyes are shining suspiciously in newborns.