Rimantadine for children not to apply to a year
Rimantadine (INN - rimantadine) - an effective antiviral drug that is available in tablets (rimantadine, Alguire; polished, rimantadine, NS., Rimantadine, STI, rimantadine, UWI,rimantadine, FPO, rimantadine hydrochloride, flumadin) and syrup (orvirem).
mechanism of action
rimantadine action based on the fact that it inhibits the multiplication of viruses after their introduction into the cell, so it is active in the first hours and days of disease.Under the action of rimantadine decreases acidity within cells which were viruses that prevents penetration of genetic material into the cell cytoplasm and virus reproduction.Rimantadine also inhibits virus yield from the cells, that is, not allowing them to spread to neighboring cells.
Sensitive to rimantadine influenza A (especially A2) and tick-borne encephalitis viruses.In addition, rimantadine can reduce symptoms of toxicity in diseases caused by not only the influenza A virus, and influenza B. Finally, rimantadine has immunostimulatory properties, as it stimulates the production of alpha- and gamma-interferon and increases the functional activity of lymphocytes involvedduring cellular immunity.
After oral rimantadine is rapidly absorbed in the intestine, where it comes first in the blood, and then distributed to tissues.Thus, in the nasal cavity it contains more than in the blood.After 24-36 hours, it is decomposed in the liver and excreted by the kidneys in an unmodified form part of a part - in the form of metabolic products.The danger here is that when the kidney function it can accumulate in the body in toxic concentrations.Therefore, it is not permitted to apply to children up to a year in which kidney function is still imperfect.
Assign rimantadine to children both for treatment and for prevention of influenza during an epidemic.Appointment rimantadine before the disease reduces the risk of getting the flu and reduces the severity of its course.When assigning rimantadine after onset of the disease (if not older than 18 hours) are less effective, however, against its receive notes easier for the disease.For children, especially, visiting children's groups, it is desirable to take rimantadine as a prophylactic measure, in this case reduced the incidence in children's groups and course of the disease in those children who are still sick, becoming less severe.
How to take rimantadine children?
Rimantadine tablets allowed to take the children to 7 years in syrup - to one year.Prior year rimantadine is not prescribed.Schemes destination rimantadine children:
- pills at the age of 7 to 10 years - 1 tablet 2 times a day for 5 days;
- pills in age from 11 to 14 years - 1 tablet 3 times a day for 5 days;
- reception syrup rimantadine (orvirema) from 1 year to 3 years: on the first day of 2 teaspoons (10 ml or 20 mg) three times a day, the second and third day - 2 teaspoons 2 times a day, the fourth day- 2 teaspoons 1 per day;
- reception syrup rimantadine (orvirema) for children from 3 to 7 years: the first day of 3 teaspoons (15 ml or 30 mg) three times a day, the second and third day - 3 teaspoons 2 times a day, the fourth day- 3 teaspoons 1 per day.
rimantadine for influenza prophylaxis prescribed one tablet 1 time a day for two weeks, the children after 7 years.
Rimantadine should not be used when you are hypersensitive to the child, as well as for violations of liver and kidney function and elevated thyroid function thyroid gland - is responsible for your hormones .This is due to the fact that the drug is decomposed in the liver and excreted through the kidneys, if the function of some of these bodies is broken, then there is an accumulation of rimantadine in the body, which is very dangerous for the baby.With the increased function of the thyroid gland (hyperthyroidism), rimantadine is not prescribed, since it has the side effect of irritability Irritability - Try to control your mood , insomnia, trembling limbs - all these features are typical for hyperthyroidism Hyperthyroidism: increasedsecretion of thyroid hormones , so the disease can be exacerbated.
wary appoint rimantadine and convulsive readiness of the child, especially in epilepsy, as remandadin may exacerbate these effects.Some children in its application may arise from violations of the digestive system - poor appetite, nausea, vomiting, abdominal pain Abdominal pain: Types and Symptoms .If these phenomena are expressed insignificantly, the receiving rimantadine can not interrupt, but expressed signs of disorders of the gastrointestinal tract should be abolished.
may also appear weakness, headaches, dizziness and impaired concentration.If a child suffers heavily rimantadine, it is better not to apply.
Allergic reactions can be expressed in the form of urticaria and itching.When allergy rimantadine should be lifted immediately.