Manufacturer Ursofalk (German pharmaceutical company Dr. Falk Pharma) in a specially designed instructions for use of the drug does not recommend taking it during pregnancy.However, today there are data on the use of the drug in pregnant women when they develop signs of stagnation of bile.
Why during pregnancy may be needed Ursofalk
during pregnancy under the influence of hormones changes the operation of all organs and body systems.First of all, during this period it produced a large number of the female sex hormone progesterone Progesterone - norm and pathology , which inhibits motor activity of smooth muscles of the abdomen and pelvis.This is necessary in order to suppress the contractility of the smooth muscle of the uterus and prevent spontaneous miscarriage Miscarriage - whether it can be insured? .The motor activity of smooth muscles of the rest of inhibited friendly and improve its activity during pregnancy is not recommended, as this may cause an increase in uterine tone.
Therefore, since the first weeks of pregnancy women are concerned constipation Constipation - Watch out for food : impaired motor activity of the intestine.The increase in the volume of the uterus only exacerbates unpleasant sensations as the uterus backs bowel and immobilize him even more.
Likewise is the case with biliary ways: violated their physical activity and output of bile.Therefore, pregnant women may develop the phenomena of cholestasis - bile stasis.
How does cholestasis of pregnancy
During cholestasis is a violation of excretion of bile and its stagnation in the intrahepatic bile ducts.This leads to the fact that toxic bile acids begin to be absorbed into the blood of women.
cholestasis of pregnancy The main symptom is itching.Most often it occurs in the third trimester of pregnancy after the 30th week.But some of the more sensitive it can disturb women from the beginning of pregnancy.Less often there is such a sign, as jaundice.Stagnation of bile can lead to the formation of the biliary tract and gall bladder Gall bladder: structure and function cholesterol stones.It is therefore possible attacks of biliary colic - sharp cramping pain in the right upper quadrant of the passage of gall pathways of cholesterol stones.
established that such a condition may affect on the child, lead to stillbirth.
How to treat cholestasis of pregnancy
today for the treatment of cholestasis of pregnancy is increasingly prescribe drugs ursodeoksiholovoy acid - ursofalk and ursosan.These drugs belong to the choleretic - they activate the secretion of bile and promote its withdrawal from the biliary tract.Under the action ursofalk blood cholesterol level is reduced, since it inhibits the enzyme involved in its formation.Reducing the amount of cholesterol prevents the formation of cholesterol stones.
Unfortunately, adequate clinical studies on the effects on the body Ursofalk pregnant woman and the fetus to date there.The laboratory studies in animals showed no mutagenic (changes in genetic fetus) and carcinogenic (to cause cancer) action of this drug.Theoretically
ursodeoksiholovoy acid supplementation may cause increased uterine tone as bile acids (ursodeoksiholovaya acid - is one of the bile acids, moreover, under the influence ursofalk increased excretion of bile into the intestine), getting into the bowel, increase its motor activity.At the same time may increase and the motor activity of muscles of the uterus.But clinical data on the effect of such Ursofalk today does not exist.
So sometimes obstetricians and internists antenatal still ursofalk prescribed to pregnant women in the development of their intrahepatic cholestasis.But it is conducted under the supervision of a physician and under the control of ultrasound (US).
If cholestasis increases with the duration of pregnancy, the woman is usually recommended to premature delivery is for a period of 35 to 38 weeks, when ultrasound confirms sufficient maturity of the fetus.Such tactics of pregnancy can prevent the toxic effects of bile acids on the fetus in the latest and most dangerous in this regard weeks of pregnancy.
Ursofalk during pregnancy is used strictly on the evidence, weigh the pros and cons.At the same time the anticipated benefits to the mother's body to exceed the potential risk to the fetus, as research on what action ursofalk has on the body of the fetus, have been conducted.And certainly a pregnant woman can not use this drug on their own without a doctor's prescription.