Rimantadine during pregnancy: impact on the fetus
Rimantadine (rimantadine) is not indicated during pregnancy because it can cross the placenta to the fetus and has a number of side effects that can adversely effect both the pregnant woman and the developing fetus.For prevention of influenza in this case it is necessary to use other means, such as interferon.
mechanism of action of rimantadine
Rimantadine - is an antiviral drug that inhibits the multiplication of viruses at an early stage, ie at the time of their introduction into the cells of the human body.It operates for 6 - 8 hours, then rapidly decomposed in the liver to metabolites (metabolite).Less than a quarter of the dose is excreted in the urine in unchanged form via the kidneys.It was then, lies the main danger, as the kidneys and so women are a double burden and rimantadine can linger in the blood.Doses higher than normal may have a toxic effect on the body.The body of a pregnant woman is particularly sensitive to any kind of toxic stress.Even a drug that can be applied to most patients in pregnancy are often contraindicated.
Furthermore, the influenza virus is located within the cells of the human body and it is impossible to work, absolutely without damaging the cells.There is no assurance that the action of rimantadine are damaged cells of vital organs, such as kidneys.And if a healthy person it happens completely transparent, the slightest change in the pregnancy status of various organs necessarily affect the status of the fetus.
What is dangerous for pregnant women rimantadine
Clinical trials of the drug in pregnant women and nursing mothers have not been conducted, but animal experiments found that rimantadine crosses the placental barrier and is excreted in breast milk.Rimantadine concentration in breast milk after three hours after a single dose than the concentration in the blood plasma.In the presence of high load on the kidneys, pregnant women and increasing the concentration of rimantadine in her blood plasma, it becomes really dangerous to the fetus.
Side effects of rimantadine may also adversely affect the pregnancy.For example, the side effects from the digestive organs, like stomach pain Abdominal pain: Types and Symptoms , bloating, abnormal liver function, dry mouth, disturbances of appetite, nausea, vomiting may exacerbate symptoms of early pregnancy toxemiaas well as violations of the digestive system that arise during the whole period of pregnancy, such as bloating and constipation.
side effects of the central nervous system (headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety anxiety - how to distinguish normal from disease? , irritability, fatigue, convulsive readiness) also exacerbateSome discomfort during pregnancy.Especially undesirable effects such gain in the second half of pregnancy, when a woman is threatened toxicosis second half (preeclampsia).Rimantadine in this case is able to stimulate the rise in blood pressure, which is typical for gestosis.And in severe preeclampsia he can provoke increased cerebrovascular accidents and seizures in pregnant women.
Reception officially rimantadine is also contraindicated in case of hypersensitivity to the drug, severe liver disease in violation of their functions (due to the increased concentration of drug in the blood of pregnant women, which is unacceptable), under any kidney disease (iethe same as a high concentration of rimantadine in blood plasma) at elevated thyroid function thyroid gland - is responsible for your hormones (this reinforces the increased excitability and nervousness, and so peculiar how such patients and pregnant women), and childrenup to one year (the toxic effect of this drug may be harmful for them because of the imperfection of the liver and kidneys).
with caution and only on prescription rimantadine are recommended in the convulsive readiness (including epilepsy), stroke, and diabetes mellitus - threatening and incurable disease - all these problems are particularly aggravated during pregnancy.
therefore apply rimantadine during pregnancy is contraindicated.During the influenza epidemic and the flu pregnant woman is much safer to use human interferon, which have no contraindications, as are natural drugs.Better yet, a pregnant woman during a flu epidemic did not attend public places (shops, cinemas), not to go to public transport as far as possible cases of influenza isolated from family members.
Rimantadine - it's a good antiviral drug, but it is contraindicated in pregnant women.